Mainly in-coming correspondence to John V. LeMoyne, received between 1852-1875. The majority of the letters are from family members and friends in Washington, Pennsylvania, including Mary Anderson, Nettie Kennedy, Francis Julius LeMoyne, Frank LeMoyne, Jane LeMoyne, Julia LeMoyne, Madeline LeMoyne, Madeline Romaine Bureau LeMoyne, Nannie LeMoyne, Romaine LeMoyne, Thurston LeMoyne, Lizzie Shaler, Charlotte Wills, John Wills, and Wilma Wills. These letters focus on family affairs in Washington, Pennsylvania, and show his mother's strong religious beliefs. There are also a few letters from LeMoyne's father cautioning his son against speculating on Chicago real estate. Among other matters, letters from friends discuss opportunities in the West (Texas, California, Oregon) and the business climate in Milwaukee.

Also included are business and calling cards, a Gentian Club (Pittsburgh?) contract and members list, a letter from St. James Church in Chicago accepting LeMoyne's resignation as choir director, and a Shakespeare ticket.