Mainly Farnsworth's correspondence, memoirs, poetry, poetry translations, photographs of family and friends, and other miscellany, 1900-1977. Correspondence, dating primarily from 1967 to 1977, is with friends and family, publishers and lawyers. There are six letters from Eugenio Montale, two addressed to him, and one to Albino Pierro.

Dating mainly from the period of her retirement, Farnsworth's works include her memoirs, her own poetry and her translations of the verses of Italian poets including Eugenio Montale, Albino Pierro, Vincenzo Cardarelli, Gabriele D'Annunzio, Alfonso Gatto, Mario Luzi, Sandro Penna, Clemente Rebora, Camille Sbarbaro, and Giuseppe Ungaretti. There are also short essays, several on Italian poets.

Included are six journals kept by Farnsworth which contain her memoirs and other writings. In the first three volumes are Farnsworth's memoirs which discuss her childhood in Chicago, Winnetka, and Wisconsin lumbering villages; her education at a Berkshires boarding school, the University of Chicago, and in Italy; her medical internship, fellowship and practice at the Passavant Hospital, and her research work in nephritis; and her association with architect Mies van der Rohe during the design and construction of the Farnsworth House at Plano, Illinois. The fourth journal contains her translation into Italian of "The Little Locksmith" by her life-long friend, Katharine Butler. The fifth and sixth volumes contain poetry translations, as do all the other volumes.

There are also several works by individuals other than Farnsworth, including poems by Eugenio Montale and a journal kept by Albert Martin Kales, a Chicago lawyer.

There are photographs of Farnsworth as a child, alone and with her sister, Marion, and mother, Alice, as well as photographs of other family members and of Eugenio Montale. In addition there are interior and exterior shots of the Farnsworth House, and a ca. 1900 view of lumber workers, probably in Wisconsin, taking a lunch break.